Relevance. Traditional coagulants for water treatment based on aluminum or iron salts are no longer able to solve the tasks assigned to them, and stricter requirements for purified water dictate the need to search for new methods and reagents for water treatment. The most promising direction for improving the efficiency of water purification is the introduction of complex titanium-containing reagents that have demonstrated high efficiency in wastewater treatment of complex composition. Aim. To compare the coagulation efficiency of traditional and complex titanium-containing coagulants in the wastewater treatment of the dairy and fat-and-oil industry. Results and conclusions. The paper investigates the effectiveness of traditional aluminum-containing coagulants (aluminum oxychloride, iron (III) chloride) and a complex sulfate-chloride coagulant based on aluminum salts modified with titanium compounds. It is shown that the use of complex sulfate-chloride coagulant allows the most effective reduction of the chemical oxygen consumption index, reflecting the content of organic compounds in water, while traditional coagulants are significantly inferior in the effectiveness of reducing this indicator. The use of a complex reagent made it possible to significantly minimize the residual content of suspended solids at lower effective doses of coagulant (60–80 mg/dm³ for complex sulfate-chloride coagulant – 95–98% purification efficiency versus 80 mg/dm³ – no more than 44–52.5% for traditional reagents) for the wastewater samples under study compared with traditional reagents. It is proved that the combination of coagulation purification with the use of complex sulfate-chloride coagulant and the flotation makes it possible to achieve the discharge standards established by the Vodokanal for the content of fats and suspended solids.