Relevance. According to the plans of the Russian Government, domestic liquified natural gas production should grow to 80–140 million tons per year by 2035, or by 146–331% compared to 2022. In the context of sanctions and the withdrawal of foreign licensors from Russia, in order to achieve such high production levels, it is necessary to solve the issue of independent competent design of new LNG plants and their loading infrastructure. Aim. Development of hydraulic calculation method for loading pipeline of liquified natural gas terminals. Methods. Methods of mathematical modeling, analytical methods. Results and conclusions. Based on the results of the work, the authors have justified the initial parameters for the hydraulic calculation of the liquified natural gas loading pipeline, and developed a method for the hydraulic calculation of the liquified natural gas plants loading pipeline. The developed method was tested on the liquified natural gas loading pipeline of Yamal LNG plant. From the point of boil-off gas formation reducing during liquefied natural gas loading into the tanker, the authors carried out the comparative analysis of heat flows of compression in a cryogenic pump and liquefied natural gas circulation in the pipeline. It is concluded that it is advisable in the technological design of the liquefied natural gas loading pipeline to apply an approach, in which one should strive to reduce the cryogenic pump discharge pressure. The developed methodology may be proposed as an addition to the Departmental Norms of Production Engineering of facilities for the production and storage of liquefied natural gas.