The relevance of the research is caused by the need to increase a resource of operational life of pressure sensors at oil pipeline operation. Now all enterprises of oil products transportation apply different types of sensors and gages when developing technological processes that gives the chance to initiate fully automated production. When developing such productions much attention is paid to the choice of sensors for obtaining reliable and exact data and extension of their service life that is directly related to reliability of designs and units of a pipe. At the same time, it is necessary to consider influence of pipe parameters and the pumped-over liquid on dynamics of a sensitive element of a sensor as it will allow providing not only necessary accuracy, but it will also increase reliability of a system “pressure sensor - pipeline” and as a result reliability of the system as the whole. Breakage of the equipment or incorrect diagnostics can lead not only to a stop of oil products pumping, but also to the breakage of the system as the whole that corresponds to serious economic and environmental problems. Thus, the task of studying the adequate mathematical model connecting dynamics of a sensitive element of the pressure sensor and pressure in the pipeline is relevant now. The main aim is to define the influence of oil pipeline parameters, pumped-over liquid, and pressure in a pipe on a sensitive element deflection in a pressure sensor located on a pipe sidewall. Object: mathematical model of interaction of liquid pumping pipeline and pressure sensor at its location on a pipe sidewall. Methods: simulation, analysis and assessment of influence of a pipeline and pumped-over liquid parameters on sensor sensitive element deflection. Results. Study of the influence of transported liquid and pressure sensor parameters on the change of sensitive element deflection of the considered device has shown that it is necessary to consider such parameters of the sensor as Poisson's coefficient and sensitive element thickness when selecting pressure sensors. It was determined as well that the density of the pumped-over liquid effects most of all the sensor sensitive element deflection. Using the Simulink application of the MatLab program the authors studied the most widespread pressure sensor of DMD 331'A'S'AX. It was defined that the amplitude of an oscillations sensitive element is 3,5 mm and oscillations time is 180 seconds in case of the most allowable pressure of 9,8 MPa at high measured pressure in a pipe. At increase in pressure the process becomes dispersing that signals a membrane rush.