The relevance of research. For the first time five potential levels of oil-and-gas collectors and confining beds have been identified in the Vendian-Cambrian section of the Predyenisey oil-and-gas area. These results obtained by the detailed lithological studies of borehole cores (the Averinskaya-150; Vezdehodnaya-3,4; Vostok-1,3,4; Lemok-1) and generalization of the actual geological and geophysical information about the region. These wells were drilled in the southern part of the Predyenisey sedimentary basin. The main aim of the study is to determine scientific directions of searching for oil and gas fields in the territory of the Predyenisey oil-and-gas area. The methods used in the study: detailed description of core boreholes, petrographic study of the rocks, genetic analysis of various types of sediments and clarification of the conditions of their sedimentation, analysis of GIS results, paleontological studies, temporary seismic sections, study of the void space of rocks in cores and thin sections, analysis of the results of testing wells and reservoir properties, establishment of relationship between lithological features of the rocks and their reservoir properties. The results. The authors identified that formations of stromatolite laminites and grapestones have the best primary reservoir properties. Postsedimentary changes appeared most intensively in these rocks that promoted formation of the cavity-fracture reservoir rocks. Five potential oil and gas reservoirs in the Vendian-Cambrian section were determined.